Understanding the potential for widespread plague resistance in prairie dogs
Prairie dogs are keystone species of North America’s central grasslands, and have experienced dramatic population reductions over the past century due to sylvatic plague, a highly virulent disease introduced to North America ca. 1900. The APE lab is involved in building a novel host-resistance modeling framework to investigate the genetic, demographic and environmental conditions that promote or impede resistance to plague and other similar virulent pathogens in complex and dynamic ecosystems. The prairie dog-plague system provides an excellent model to understand the conditions under which evolutionary rescue occurs in complex and dynamic ecological systems, and will help illuminate a novel and potential large-scale conservation approach to address 1) the biggest threat facing the prairie dog ecosystem that spans from Canada to Mexico - plague and 2) species around the world threatened with novel diseases and climate change. ...